中国临床药理学杂志2016，Vol.32Issue(14)：1293-1295,3.DOI:10.13699/j.cnki.1001-6821.2016.14.013
拉莫三嗪联合丙戊酸钠治疗小儿癫痫的临床研究
Clinical trial of lamotrigine combined with sodium valproate in the treatment of children epilepsy
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of lamotrigine combined with sodium valproate in the treatment of children epilepsy.Methods Fifty-two children with epilepsy were randomly di-vided into control group (n=26) and treatment group(n=26).Control group was given 15 mg・ kg -1・ d -1 sodium valproate oral , 2 to 3 times a day, gradually increased to 25 mg・ kg -1・ d-1 for maintenance dose within 4 weeks.Treatment group was treated with lamotrigine 0.15 to 0.30 mg・ kg-1 , qd, gradually increasing to 1.00-5.00 mg・ kg -1・ d-1 in 8 weeks, on the basis of the control group.Two groups were treated for 4 months. The clinical efficacy , serum tumor necrosis factor -α(TNF-α), high-sensitivity C -reactive protein (hs-CRP), homo-cysteine ( Hcy ) , hematocrit ( HCT ) , erythrocyte sedimentation rate ( ESR) and incidence of adverse drug reactions were compared between two groups.Results After treatment, the total effective rate of treatment group was 92.31%( 24/26 ) , which was significantly higher than that of control group [ 69.23%( 18/26 ) , P<0.05 ] .After treatment , among the treatment and control group, the levels of serum TNF -αwere ( 28.73 ±3.04 ) , ( 54.84 ±5.63 ) pg・ mL -1 , hs -CRP were ( 4.92 ±0.52 ) , ( 8.02 ±1.01 ) mg・ L -1 , Hcy were ( 11.84 ±1.21 ) , (16.64 ±2.03)μmol・ L -1, HCT were(40.28 ±4.37)%, (43.98 ±5.28)%, ESR were (3.02 ±0.34), (3.89 ±0.46)mm・ h -1, and those indexes after treatment in treatment group were significantly lower than those in control group (P<0.05).The adverse drug reactions were based on the symptoms of nervous system for two groups.Also, the incidence of adverse drug reactions of control and treatment groups were 11.53%and 19.23%( P>0.05 ) .Conclusion Lamotrigine combined with sodium valproate has a definitive clinical efficacy and safety for the treatment of children epilepsy.关键词
拉莫三嗪/丙戊酸钠/小儿癫痫/安全性Key words
lamotrigine/sodium valproate/epilepsy/safety分类
医药卫生引用本文复制引用
贾妮..拉莫三嗪联合丙戊酸钠治疗小儿癫痫的临床研究[J].中国临床药理学杂志,2016,32(14):1293-1295,3.基金项目
陕西省自然科学基础研究计划基金资助项目 （）
