中国临床药理学杂志2016，Vol.32Issue(14)：1311-1313,3.DOI:10.13699/j.cnki.1001-6821.2016.14.018
别嘌呤醇改善高果糖诱导的大鼠胰岛素抵抗的实验研究
Experimental study of allopurinol on insulin resistance in high-fructose rats
摘要
Abstract
Objective To investigate allopurinol ( a xanthine oxidase in-hibitor) improves insulin resistance of rats fed with high -fructose diet. Methods Male Wistar rats were randomly divided into 3 groups and each group was fed one of the following diets for 4 weeks:standard chow diet(normal group), high -fructose diet(model group), and high -fructose diet plus allopurinol(allopurinol 25μg・ g-1, test group).Insu-lin sensitivity index was assessed from the oral glucose tolerance test ( OGTT) and the euglycemic clamp studies .Results Serum uric acid and plasma insulin concentrations were significantly decreased with allo-purinol treatment.That the serum uric acid of the model group with (1.82 ±0.10 ) mg・ dL-1 was significantly increased than normal group with ( 1.33 ±0.12 ) mg・ dL-1 , and improved by test group with (0.90 ±0.27) mg・ dL-1.There was no difference in the levels of glu-cose with OGTT among the 3 groups.The model group produced a marked decrease in insulin sensitivity index ( GIR) compared with normal group (P<0.05).Allopurinol treated high -fructose fed rats showed a signifi-cant increase in GIR , reaching a similar level as that of the normal group (P<0.05).Conclusion Allopurinol may improve of insulin resistance in high-fructose induced insulin resistant .关键词
别嘌呤醇/高果糖/胰岛素敏感性/高胰岛素-正常葡萄糖钳夹法Key words
allopurinol/high -fructose/insulin sensitivity index/euglycemic clamp分类
医药卫生引用本文复制引用
杨庆华,邹月华,岳学玲,陈玲,李英顺,金清华,姜海英..别嘌呤醇改善高果糖诱导的大鼠胰岛素抵抗的实验研究[J].中国临床药理学杂志,2016,32(14):1311-1313,3.基金项目
延边大学科技发展计划基金资助项目（602013102）；延边大学2016年大学生创新创业训练计划科研基金资助项目 （）
