中国免疫学杂志2016，Vol.32Issue(7)：1000-1003,4.DOI:10.3969/j.issn.1000-484X.2016.07.015
miR-126在乳腺癌中与VEGF表达关系及其抗肿瘤效果
MiR-126 expression relationship with VEGF in breast cancer and its anti-tumor effect
摘要
Abstract
Objective:To probe the expression of miR-126 and VEGF in breast cancer, and the anti-tumor effect of miR-126. Methods:The expression of miR-126 and VEGF in breast cancer tissues and cells were detected by qRT-PCR and Western blot;after transfection with miR-126 mimics into MDA-MB-231,expression of VEGF was detected again,MTT assay and cell scratch test were used to verify the influence of miR-126 on proliferation and migration of tumor cells. Results: The expression of miR-126 was lower in the breast cancer tissues and cells,the expression of VEGF was negative correlation with it,increasing the expression of miR-126 may decrease the expression of VEGF and inhibit the proliferation and migration of breast cancer cells. Conclusion:miR-126 can reduce the proliferation and migration of breast cancer cells by inhibiting the expression of VEGF,which play an anti-tumor effect.关键词
miR-126/VEGF/乳腺癌Key words
miR-126/VEGF/Breast cancer分类
医药卫生引用本文复制引用
米旭光,李首庆,刘多,魏海峰,江显卓,方艳秋..miR-126在乳腺癌中与VEGF表达关系及其抗肿瘤效果[J].中国免疫学杂志,2016,32(7):1000-1003,4.基金项目
本文由吉林省卫生厅科技计划项目(No.2012Z080 （）
2014Z012)、长春市社会发展科技计划项目(No.2012129-12SF57)和吉林省科技发展计划项目(No.20140519018JH （No.2012129-12SF57）
20122113)资助。 （）
