中国免疫学杂志2016，Vol.32Issue(7)：1042-1049,8.DOI:10.3969/j.issn.1000-484X.2016.07.025
热休克蛋白27,60和90在胃癌中表达及其临床价值
Expression of heat shock protein 27, 60 and 90 in gastric cancer and its clinical value
张占东 1杨巍 1马飞 1张永磊 1马二民 2孔烨 1刘洪兴 1花亚伟1
作者信息
- 1. 郑州大学附属肿瘤医院 河南省肿瘤医院普外科，郑州 450008
- 2. 郑州人民医院肿瘤外科，郑州 450000
- 折叠
摘要
Abstract
Objective: To investigate the expression of HSP-27,-60 and -90 in gastric cancer and its clinical significance. Methods:66 cases of gastric carcinoma was detected by immunohistochemistry HSP-27,60 and 90 of the expression and clinical significance of combined with clinical and pathological characteristics, tumor cell proliferation and survival analysis of three kinds of heat shock protein expression. Results: HSP-27,-60 and -90 were highly expressed in gastric cancer tissues. HSP-27 expression and tumor size (pT,P=0. 026),organ metastasis (pM,P=0. 046) and pathological staging (P=0. 041),HSP-27 staining intensity and lymph node status were significantly correlated ( pN, P=0. 042 ) . HSP-60 expression was associated with gender ( P=0. 011),and HSP-60 staining intensity was associated with age (P=0. 027) and tumor grade (P=0. 031). There was no correlation between HSP-90 expression and the clinical pathological parameters of this study; however, the intensity of HSP-90 staining was significantly correlated with tumor size (P=0. 020,pT). Single factor analysis showed that HSP-90 was significantly associated with longer survival (P=0. 033). Multivariate analysis demonstrated that HSP-90 was highly expressed as an independent prognostic factor for gastric cancer (P=0. 026). Conclusion: the HSP-27,-60 and -90 and some clinical pathological parameters. These parameters is very important for the treatment of patients with gastric cancer. The high expression of HSP-90 in patients with gastric cancer were inde-pendent prognostic indicators.关键词
热休克蛋白27/热休克蛋白60/热休克蛋白90/胃癌Key words
Heat schock protein( HSP)-27/HSP-60/HSP-90/Grastric cancer分类
医药卫生引用本文复制引用
张占东,杨巍,马飞,张永磊,马二民,孔烨,刘洪兴,花亚伟..热休克蛋白27,60和90在胃癌中表达及其临床价值[J].中国免疫学杂志,2016,32(7):1042-1049,8.
