中国普通外科杂志2016，Vol.25Issue(7)：1017-1022,6.DOI:10.3978/j.issn.1005-6947.2016.07.014
细胞分裂周期蛋白6在肝细胞癌中的表达及其临床意义
Expression of cell division cycle6 in hepatocellular carcinoma and its clinical significance
吕波 1李明杰 2郑小林 1蔡常春1
作者信息
- 1. 华中科技大学同济医学院附属武汉市中心医院 肝胆胰外科，湖北 武汉430014
- 2. 上海交通大学医学院附属瑞金医院 普通外科，上海 200025
- 折叠
摘要
Abstract
Objective: To investigate the expression of cell division cycle 6 (CDC6) in hepatocellular carcinoma (HCC) and its clinical signiifcance. <br> Methods: hTe mRNA and protein expressions of CDC6 in 85 surgical specimens of HCC tissue and matched adjacent tissue were determined by qRT-PCR, Western blot analysis and immunohistochemical staining, respectively. The relations of CDC6 expression with clinicopathologic characteristics and prognosis of HCC patients were analyzed. <br> Results: Both mRNA and protein expression levels of CDC6 were increased in HCC tissue compared with adjacent tissue, and quantitative analysis of qRT-PCR results showed that the difference had statistical signiifcance (P<0.05). hTe CDC6 expression was signiifcantly related to tumor size, clinical stage, degree of differentiation and satellite lesions (allP<0.05). Both tumor-free survival rate and overall survival rate in patients with high CDC6 expression were signiifcantly lower than those in patients with low CDC6 expression (bothP<0.05), and both univariate and multivariate analyses showed that CDC6 was an independently risk factor for tumor-free survival rate (HR=1.089, 95%CI=0.986–1.186,P=0.033) and overall survival rate (HR=2.441, 95%CI=1.128–3.652, P=0.012) in HCC patients. <br> Conclusion: CDC6 is highly expressed in HCC tissue, and is closely related to malignant clinicopathologic features and poor prognosis. CDC6 may contribute to the occurrence and development of HCC, and may be used as an index for estimating tumor recurrence and outcomes.关键词
癌,肝细胞/细胞分裂周期蛋白质类/预后Key words
Carcinoma, Hepatocellular/Cell Cycle Proteins/Prognosis分类
医药卫生引用本文复制引用
吕波,李明杰,郑小林,蔡常春..细胞分裂周期蛋白6在肝细胞癌中的表达及其临床意义[J].中国普通外科杂志,2016,25(7):1017-1022,6.
