中国兽医杂志2016，Vol.50Issue(6)：44-47,4.
阿莫西林在藏系羊体内的药物动力学研究
Studies on Pharmacokinetics of Amoxicillin in Tibetan Sheep
闫丽萍 1史权军 1何斌2
作者信息
- 1. 青海省湟中县动物卫生监督所，青海湟中 811600
- 2. 武汉市农业科学技术研究院畜牧兽医科学研究所，武汉 430208
- 折叠
摘要
Abstract
The experiment mainly focuses on research of characteristic of pharmacokinetics of amoxicillin in Tibetan sheep,providing the basis for clinical veterinary drug.8 adult Tibetan sheep are randomly selected with oral administration of amoxicillin,drug concentration testing in plasma by adopting high performance liquid chromatography.The main pharmacokinetic parameters after oral administration of amoxicillin are :t1 /2αare 0.773 ±0.097 h,t1 /2ka are 0.156 ±0.021 h,t1 /2βare 3.787 ±0.973 h,AUC are 8.249 ±1.023 μg·h /mL,Tmax are 0.497 ±0.036 h,Cmax are 2.667 ±0.198 μg/mL.The result demonstrates that amoxicillin are absorbed quickly in Tibetan sheep by oral administration with rapid disappearance.关键词
阿莫西林/高效液相色谱/藏系羊/药物动力学Key words
amoxicillin/HPLC/Tibetan sheep/pharmacokinetics分类
农业科技引用本文复制引用
闫丽萍,史权军,何斌..阿莫西林在藏系羊体内的药物动力学研究[J].中国兽医杂志,2016,50(6):44-47,4.
