中国畜牧兽医2016，Vol.43Issue(7)：1674-1680,7.DOI:10.16431/j.cnki.1671-7236.2016.07.003
牛磺鹅去氧胆酸对小鼠巨噬细胞系RAW264.7细胞凋亡的影响
Effect of Taurochenodeoxycholic Acid on the Proliferation of the Mouse Macrophage Cell Line RAW264.7
摘要
Abstract
We carried out the research of the effect of taurochenodeoxycholic acid (TCDCA)on the apoptosis of the mouse macrophage cell line RAW264.7 and expression of IAPs including CIAP-1,CIAP-2 and XIAP.The results showed that TCDCA with the dose of 0.05,0.10 and 10μg/mL could extremely significantly prevent cells apoptosis that were induced by DEX (P<0.01).TCDCA with the dose of 1μg/mL could significantly promote mRNA expressions of CIAP-1 and XIAP (P<0.05),while the dose of 10μg/mL could significantly promote mRNA ex-pressions of CIAP-1,CIAP-2 and XIAP (P<0.05),TCDCA could also extremely significantly up-regulate the expression of CIAP-1,CIAP-2 and XIAP (P<0.01)in RAW264.7 cell line by DEX, but this depended on different doses of TCDCA.The above research results showed that TCDCA could resist the cells apoptosis of the mouse macrophage cell line RAW264.7 that were induced by DEX,which was related with the influence on the mRNA expression of IAPs.关键词
牛磺鹅去氧胆酸/小鼠巨噬细胞系 RAW2 6 4 .7/细胞凋亡/凋亡抑制蛋白Key words
taurochenodeoxycholic acid/mouse macrophage cell line RAW264.7/cell apoptosis/IAPs分类
生物科学引用本文复制引用
张文,王建光,李金莲,赵孝民,陈正涛,周川,石有斐..牛磺鹅去氧胆酸对小鼠巨噬细胞系RAW264.7细胞凋亡的影响[J].中国畜牧兽医,2016,43(7):1674-1680,7.基金项目
国家自然科学基金(30800837) （30800837）
山东省高等学校科技计划项目(J13LE53) （J13LE53）
山东省博士后基金(76404) （76404）
