中国药房2016，Vol.27Issue(20)：2790-2794,5.DOI:10.6039/j.issn.1001-0408.2016.20.17
4种第二代抗精神病药物治疗精神分裂症急性期的临床观察
Clinical Observation of 4 Kinds of the Second-generation Antipsychotic Drugs in the Treatment of Acute Phase of Schizophrenia
摘要
Abstract
OBJECTIVE:To investigate clinical efficacy and adverse reactions(ADRs)of 4 kinds of the second-generation anti-psychotic drugs in the treatment of acute phase of schizophrenia. METHODS:159 patients with schizophrenia were randomly divid-ed into risperidone group(40 cases),olanzapine group(40 cases),aripiprazole group(39 cases)and ziprasidone group(40 cas-es). All groups were given routine dosage of relevant medicine by routine usage for 6 weeks. Mental status of patients were mea-sured by PANSS before treatment and after 2,4 and 6 weeks of treatment. At the same time,blood glucose,blood lipid,prolac-tion and other metabolic and biological indicators were all detected. RSESE,BARS and UKU were adopted to evaluate ADR. RE-SULTS:A total of 100 patients completed the study. Compared with aripiprazole group and ziprasidone group,risperidone and olan-zapine inhibited symptom more rapidly,with statistical significance (P<0.05). After treatment,body mass index and abdominal circumference of olanzapine group were significantly higher than those of other 3 groups,with statistical significance (P<0.05). Low density lipoprotein of olanzapine group was increased significantly,there was statistical significance compared to ziprasidone group and aripiprazole group(P<0.05). Prolactin level of risperidone group was significantly higher than those of other 3 groups, while that of aripiprazole group was significantly lower than those of other 3 groups,with statistical significance(P<0.05). ADRs of 4 drugs were mild or moderate,most of whom could be alleviated by symptomatic treatment. CONCLUSIONS:In the treatment of acute phase schizophrenia,4 drugs of the second-generation have similar curative effect in symptoms control,among which ris-peridone and olanzapine inhibit positive symptom more rapidly while more ADRs that related to lipid and glucose metabolism and prolactin also show. Aripiprazole and ziprasidone induce less ADRs relatively,and patients show better tolerability. Physicians should consider all kinds of factors in drugs selection,and make individualized treatment plan.关键词
第二代抗精神病药物/精神分裂症/急性期/利培酮/奥氮平/阿立哌唑/齐拉西酮/临床疗效/不良反应Key words
The second-generation antipsychotic drugs/Schizophrenia/Acute phase/Risperidone/Olanzapine/Aripiprazole/Ziprasidone/Clinical efficacy/Adverse reactions分类
医药卫生引用本文复制引用
赵晶媛,黄光彪,顾小静,艾小青,杨淑珍,华婷婷,吕路线..4种第二代抗精神病药物治疗精神分裂症急性期的临床观察[J].中国药房,2016,27(20):2790-2794,5.基金项目
国家自然科学基金资助项目（No.81371472）；河南省科技项目 （）
