中国医科大学学报2016，Vol.45Issue(7)：620-625,6.DOI:10.12007/j.issn.0258-4646.2016.07.010
3.0T磁共振动态对比增强扫描在脑胶质瘤分级诊断中的应用
Application of 3.0T Dynamic Contrast-enhanced MRI in the Grading of Gliomas
宋加哲 1胡兰花 1范国光 1李松柏1
作者信息
- 1. 中国医科大学附属第一医院放射科，沈阳 110001
- 折叠
摘要
Abstract
Objective To explore the clinical significance of 3.0T dynamic⁃contrast enhanced MRI scan in the grading of intracranial glioma. Methods The magnetic resonance examination were performed in 40 cases of patients of brain tumors confirmed by surgery pathology(29 pa⁃tients with glioma),including conventional MRI and dynamic contrast⁃enhanced MRI. Using Kinetic Modeling⁃version 3.0 software on the GE 3.0T magnetic resonance workstation calculation of intracranial tumor parenchyma area corresponding quantitative parameters Ktrans and Ve values. The quantitative parameters between any two classification were compared ,and the difference was statistically analyzed. The characteristics of the different level of intracranial glioma's dynamic enhanced scan parameters were preliminary analyzed. The receiver⁃operating characteristic curve (ROC)analysis of Ktrans value and Ve value was performed,and the diagnosed threshold,sensitivity and specificity were acquired. Results While applying dynamic⁃contrast enhanced MRI scan acquired Ktrans and Ve values ,both values of high grade gliomas include gradeⅢandⅣwere significantly higher than that of low grade gliomas include gradeⅠandⅡ(P<0.05);there was no statistically difference of the parameters of Ktrans and Ve values between gradesⅠwithⅡand gradeⅢwithⅣ(P>0.05). To identify low grade gliomas with high grade glioma ,Ktrans and Ve diagnosis threshold was 0.204/min and 0.099 respectively. To distinguish between gradeⅡandⅢglioma,Ktrans and Ve diagnosis threshold was 0.247/min and 0.176 respectively. Conclusion Combining quantitative parameters Ktrans and Ve value that come from 3.0T dynamic con⁃trast enhanced MRI scan with regular enhancement MRI can distinguish low grade gliomas with high grade gliomas glioma ,as well as distinguish gradeⅡwithⅢglioma;However,it is still difficult to identify low grade gliomaⅠwithⅡ,as well as high grade gliomaⅢwithⅣ. The Ktrans and Ve value plays an important role in discriminate different grade intracranial tumors in a preoperative noninvasive way.关键词
动态对比增强磁共振/脑胶质瘤/分级/诊断/容积转运常数Key words
dynamic contrast-enhanced magnetic resonance imaging/brain gliomas/grade/diagnosis/volume transfer constant分类
临床医学引用本文复制引用
宋加哲,胡兰花,范国光,李松柏..3.0T磁共振动态对比增强扫描在脑胶质瘤分级诊断中的应用[J].中国医科大学学报,2016,45(7):620-625,6.
