中国医科大学学报2016，Vol.45Issue(8)：673-677,5.DOI:10.12007/j.issn.0258-4646.2016.08.001
散发性乳腺癌中Ezrin和β-catenin蛋白表达的相关性和临床意义
Correlation and Clinical Significance of Ezrin and β-catenin Protein Expression in Sporadic Breast Cancer
摘要
Abstract
Objective To explore the clinical significance of Ezrin and β⁃catenin in breast cancer. Methods Immunohistochemical staining method was adopted to detect Ezrin and β⁃catenin protein expression level in 145 cases of breast cancer tissues,and their correlation with clinical data and prognosis of breast cancer was analyzed. Results Ezrin was expressed in 70 cases(48.3%),β⁃catenin was expressed in 82 cases (56.6%),and there was significantly negative correlation(r=0.267,P=0.001). The higher histologic grade of breast cancer,the higher expres⁃sion level of Ezrin(P=0.007),and the lower expression level of β⁃catenin(P<0.001). Ezrin expression level was increased significantly(P=0.027),but β⁃catenin expression level was reduced significantly(P=0.011)in lymph node positive breast cancer tissue. Ezrin expression was sig⁃nificantly correlated with shorter overall survival(P=0.004)and disease free survival(P=0.017)of breast cancer patients,but β⁃catenin expres⁃sion was significantly correlated with longer overall survival(P<0.001)and disease free survival(P=0.001)of breast cancer patients. However , Ezrin and β⁃catenin were not the independent risk factors of breast cancer patients as determined by multivariate Cox regression. Conclusion Ez⁃rin was significantly negative correlated with β⁃catenin in breast cancer. They play a role in the progression and poor prognosis of breast cancer , which can be used as breast cancer treatment targets.关键词
乳腺癌/埃兹蛋白/β-连环蛋白/转移/预后Key words
breast cancer/Ezrin/β-catenin/metastasis/prognosis分类
医药卫生引用本文复制引用
赵琳,于兆进,何苗,孙明立,魏敏杰..散发性乳腺癌中Ezrin和β-catenin蛋白表达的相关性和临床意义[J].中国医科大学学报,2016,45(8):673-677,5.基金项目
国家自然科学基金（81373427）；辽宁省科学技术计划本溪生物医药产业集群项目（2014226033）；辽宁省高等学校创新团队项目 （）
