中国医科大学学报2016，Vol.45Issue(8)：688-691,4.DOI:10.12007/j.issn.0258-4646.2016.08.004
刺山柑总生物碱对系统性硬皮病小鼠Ⅲ型胶原表达的影响
Effects of Capparis Spinosa Total Alkaloid on TypeⅢ Collagen Expression in Systemic Sclerosis Mice
摘要
Abstract
Objective To investigate the effects of capparis spinosa total alkaloid on the pathological changes and the type Ⅲ collagen(COL⁃Ⅲ)expression in systemic sclerosis(SSc)mice. Methods Mice models with SSc were established by repeated local injection of bleomycin in BALB/c mice back. After administration of capparis spinosa total alkaloid ,the pathological changes of skin and lung tissue were observed ,and the COL⁃Ⅲ expression was detected by ELISA. Results Compared with the model group,the inflammation and fibrosis of skin and lung tissue were improved,and the level of COL⁃Ⅲ was markedly reduced by treatment of high dose capparis spinosa total alkaloid(P<0.05). Conclusion Cap⁃paris spinosa total alkaloid is effective in treating fibrosis of SSc.关键词
刺山柑总生物碱/系统性硬皮病/病理/Ⅲ型胶原/纤维化Key words
Capparis spinosa total alkaloid/systemic sclerosis/pathological change/typeⅢcollagen/fibrosis分类
医药卫生引用本文复制引用
康小龙,何承辉,刘晶,卢军,杨俊玲..刺山柑总生物碱对系统性硬皮病小鼠Ⅲ型胶原表达的影响[J].中国医科大学学报,2016,45(8):688-691,4.基金项目
国家自然科学基金 （）
