中国医科大学学报2016，Vol.45Issue(8)：692-694,703,4.DOI:10.12007/j.issn.0258-4646.2016.08.005
TBX1基因在透明细胞型肾细胞癌组织中的表达及意义
Expression of TBX1 Gene in Kidney Tissues in Patients with Clear Cell Renal Cell Carcinoma and Its Clinical Significance
摘要
Abstract
Objective To analyze the expression of TBX1 gene in kidney tissues in patients with clear cell renal cell carcinoma(ccRCC)and in⁃vestigate its molecular genetics mechanism during the tumor development. Methods Real⁃time quantitative polymerase chain reaction(qRT⁃PCR)was used to detect the expression of TBX1 mRNA in 12 cases of clear cell renal cell carcinoma tissues and the corresponding normal kidney tissues adjacent to carcinoma .The protein expression of TBX1 was assayed by Western blot in both groups. Results Both TBX1 mRNA level and the protein level were significantly up⁃regulated in ccRCC tissues compare to those in normal kidney tissues adjacent to carcinoma(all P<0.05). Conclusion Over⁃expression of TBX1 gene might be a potentially pathogenic mechanism of ccRCC.关键词
TBX1基因/透明细胞型肾细胞癌/实时定量聚合酶链反应/Western blotKey words
TBX1/clear cell renal cell carcinoma/RT-PCR/Western blot分类
医药卫生引用本文复制引用
姜红堃,田红宇,郭燕平,王妍,张宇曦,姜红..TBX1基因在透明细胞型肾细胞癌组织中的表达及意义[J].中国医科大学学报,2016,45(8):692-694,703,4.基金项目
国家自然科学基金（81300130）；教育部高校博士点专项基金（20122104110001）；辽宁省省直医院改革重点临床科室诊疗能力建设项目 （）
