中国医科大学学报2016，Vol.45Issue(8)：695-699,5.DOI:10.12007/j.issn.0258-4646.2016.08.006
淋巴结转移阳性乳腺癌中Ezrin相关的上皮钙黏蛋白表达亚细胞定位的临床意义
Clinical Significance of Ezrin Associated Subcellular Localization of E-cadherin Expression in Lymph Nodes Positive Breast Cancer
摘要
Abstract
Objective To investigate the relationship between Ezrin expression and subcellular localization of E⁃cadherin(E⁃cad),and explore the clinical significance of this relationship to pathological features such as lymph nodes metastasis in breast cancer. Methods Ninety four cases of breast cancer tissue samples with lymph node metastasis were collected. The expression of Ezrin and E⁃cad was detected by immunohistochemi⁃cal method. Results The positive rates of and E⁃cad and Ezrin were respectively 45.7%and 58.5%in 94 nodes positive breast cancer,containing membranal expression of E⁃cad(E⁃cadm)in 20 cases and cytoplasmic expression of E⁃cad(E⁃cadc)in 23 cases;the frequency of E⁃cadc positive staining was significantly higher in Ezrin(+)tissues than that in Ezrin(-)tissues(P=0.025);E⁃cad expression level was significantly lower in TNMⅡ⁃Ⅲstage cases(P=0.001),and Ezrin expression(P=0.036)and E⁃cadc(P=0.013)was significantly increased in bigger cases;com⁃pared with E⁃cad(+),Ezrin(-),E⁃cadm tissues,the number of lymph node metastasis in E⁃cad(-)(P=0.011),Ezrin(+)(P=0.002),E⁃cadc (P=0.020)tissues were increased significantly;in the order of E⁃cad(+)/Ezrin(-),E⁃cad(-)/Ezrin(-),E⁃cad(+)/Ezrin(+),and E⁃cad(-)/Ezrin(+),the number of lymph node metastasis was increased significantly(P<0.001);similarly,in the order of E⁃cadm/Ezrin(-),E⁃cadc/Ezrin(-),E⁃cadm/Ezrin(+),and E⁃cadc/Ezrin(+),the number of lymph node metastasis was increased significantly(P=0.007). Conclusion Ezrin may regulate the subcellular localization of E⁃cad in metastatic breast cancer ,which may affect the course of breast cancer and promote the metastasis of lymph nodes.关键词
Ezrin/上皮钙黏蛋白/亚细胞定位/乳腺癌/淋巴结转移Key words
Ezrin/E-cadherin/subcellular localization/breast cancer/lymph nodes metastasis分类
医药卫生引用本文复制引用
于兆进,何苗,孙明立,赵海山,魏敏杰,赵琳..淋巴结转移阳性乳腺癌中Ezrin相关的上皮钙黏蛋白表达亚细胞定位的临床意义[J].中国医科大学学报,2016,45(8):695-699,5.基金项目
辽宁省高等学校创新团队支持计划（LT2014016）；沈阳市科学技术计划 （）
