中国医科大学学报2016，Vol.45Issue(8)：708-710,714,4.DOI:10.12007/j.issn.0258-4646.2016.08.009
大鼠创伤性脑损伤后精神障碍的精神行为学改变
Spirit Behavioral Changes of Mental Disorders Caused by Traumatic Brain Injury in Rats
摘要
Abstract
Objective To set up traumatic brain injury(TBI)in rats by the improved device of FEENEY ’s weight dropping model and to ex⁃plore the spirit behavioral changes of mental disorders caused by TBI. Methods SD rats were randomly divided into normal control group(normal group,n=10),traumatic brain injury group(TBI group,n=10)and sham group(n=10). The improved device of FEENEY’s method was ad⁃opted to establish rat TBI model. For the following 15 days after TBI,open⁃field(OF)and forced swimming(FS)tests were carried out and the be⁃havior of the TBI rats within 5 minutes were recorded,the behavioral indexes,such as distance moved total(DMT),velocity mean(VM)and immo⁃bility time total(ITT),were analyzed. With above experiments,rats' fear response to environment,high alertness and anxiety and depression be⁃havior were evaluated. Results DMT and VM of TBI group rats(1 228.10±204.97 cm,4.09±0.68 cm/s)were significantly lower than those of the normal group(2 022.32±280.92 cm,7.28±1.80 cm/s)or sham group(1 660.01±332.09 cm,5.53±1.10 cm/s)(P<0.05).The ITT of TBI group (149.88±27.36 s,P<0.05)was longer than that of the normal group(106.10±29.03 s)or sham group(120.55±22.31 s)significantly(P<0.05). Conclusion TBI leads to rats' abnormal emotional and behavioral response.关键词
创伤性脑损伤/精神障碍/旷场实验/强迫游泳实验Key words
traumatic brain injury/mental disorders/open-field test/forced swimming tests分类
医药卫生引用本文复制引用
李力卓,何松柏..大鼠创伤性脑损伤后精神障碍的精神行为学改变[J].中国医科大学学报,2016,45(8):708-710,714,4.基金项目
辽宁省自然科学基金（2013010083-401）；沈阳市科学技术计划 （）
