中国药理学通报2016，Vol.32Issue(7)：889-893,894,6.DOI:10.3969/j.issn.1001-1978.2016.07.001
JAK／STAT信号转导通路及中药干预在缺血性脑卒中的研究进展
Research progress of JAK/STAT signal transduction pathway and traditional Chinese medicine intervention in the treatment of ischemic stroke
摘要
Abstract
Ischemic stroke, gravely affecting human health with its increasing incidence rate , is a common disease of old age . JAK/STAT way , a recently discovered signaling pathway , is not only widely involved in processes of cell growth ,differentiation, and apoptosis ,but also closely related to the pathophysiology of stroke.However,the pathway function and mechanism in ische-mic cerebral stroke has not yet been fully elucidated .We will review the role and mechanism of JAK/STAT signal transduction pathway in ischemic stroke ,and scientifically draw network chart between various related signal molecules in the process of ische-mic stroke neuropathy combining both domestic and foreign re-search reported in this paper , in order to better understand the pathological mechanism process of brain stroke , find new drugs for the treatment of cerebral ischemic diseases ,then provide more systematic scientific literature support .关键词
缺血性脑卒中/JAK/STAT信号转导通路/负反馈调控/神经元凋亡/中药/干预作用Key words
ischemic stroke/JAK/STAT signal transduction pathway/negative feedback regulation/neuronal apoptosis/inter-vention effect/Traditional Chinese medicine分类
医药卫生引用本文复制引用
杨志宏,胡亚,孙晓波..JAK／STAT信号转导通路及中药干预在缺血性脑卒中的研究进展[J].中国药理学通报,2016,32(7):889-893,894,6.基金项目
国家自然科学基金资助项目（81273654，81473579，81102879）；国家科技部“重大新药创制”科技重大专项 （）
