中国药理学通报2016，Vol.32Issue(7)：894-897,4.DOI:10.3969/j.issn.1001-1978.2016.07.002
谷氨酸转运体 EAAT2在抑郁症发病及治疗中的作用
Roles of glutamate transporter EAAT2 in occurrence and treatment of depression
摘要
Abstract
The glutamate transporter EAAT 2 ( rodent nomencla-ture GLT-1:glutamate transporter 1), which is a predominantly astroglial glutamate transporter in the hippocampus and the pre-frontal cortex , is responsible for the majority of extracellular glu-tamate uptake .The glutamate transporter EAAT 2 can decrease the high levels of glutamate in the synaptic cleft , avoiding gluta-matergic excitotoxicity to damage the glial cells and neurons . Currently, the transporter EAAT2 has become a research hotspot of depression .This article aims to summarize roles of glutamate transporter EAAT2 in the occurrence and treatment of depres-sion.关键词
谷氨酸转运体EAAT2/抑郁/抗抑郁药/转运功能障碍/利鲁唑/头孢曲松Key words
glutamate transporter EAAT 2/depression/antide-pressant/transport dysfunction/riluzole/ceftriaxone分类
医药卫生引用本文复制引用
陈建新,姚丽华,王惠玲,刘忠纯,王晓萍,肖玲,舒畅,王高华..谷氨酸转运体 EAAT2在抑郁症发病及治疗中的作用[J].中国药理学通报,2016,32(7):894-897,4.基金项目
国家级“十二五计划”项目课题（ No 2012BAIO1B05）；国家自然科学基金项目 （）
