中国药理学通报2016，Vol.32Issue(7)：898-901,902,5.DOI:10.3969/j.issn.1001-1978.2016.07.003
药物性肝损伤的代谢、遗传学机制
Drug-induced liver injury:metabolic and genetic basis
摘要
Abstract
Drug-induced liver injury ( DILI) is a significant rea-son of acute liver failure and is the main cause of therapeutic drugs withdrawal from the market .Multiple mechanisms can cul-minate in DILI , but metabolism and genetics play distinct roles in this process .This review will cover papers we consider have addressed these mechanisms of DILI in commonly used medica-tions for adults , and discuss the hot issues .The aim is to gener-ate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILI.关键词
药物性肝损伤/肝毒性/代谢/遗传/白细胞抗原/CYP450Key words
DILI/hepatotoxicity/metabolism/genetics/HLA/CYP450分类
医药卫生引用本文复制引用
王书杰,王沛,李晓天,张莉蓉..药物性肝损伤的代谢、遗传学机制[J].中国药理学通报,2016,32(7):898-901,902,5.基金项目
国家自然科学基金资助项目 （）
