中国药理学通报2016，Vol.32Issue(7)：902-905,4.DOI:10.3969/j.issn.1001-1978.2016.07.004
丹参水溶性成分影响骨代谢的机制研究进展
Research progress of regulatory effects of water-soluble compounds isolated form Salvia miltiorrhiza on bone metabolism
摘要
Abstract
Salvia miltiorrhiza is a traditional Chinese medicine for the treatment of cardiovascular diseases .Recently, increasing evidence demonstrates that the water-soluble compounds isolated from Salvia miltiorrhiza,including tanshinol and salvianolic acid B, exert a regulatory influence on bone metabolism .The under-lying mechanism of these compounds involves various pathways , such as Wnt/β-catenin, ERK, BMP, OPG/RANKL/RANK and FoxO mediated oxidative stress pathway .This paper reviews pre-vious effects and mechanism of polyphenolic acids in Salvia milt-iorrhiza , which may provide the base for the research and devel-opment of the new agents to treat osteoporosis .关键词
丹参/水溶性成分/丹参素/丹参酚酸B/骨代谢/骨质疏松Key words
Salvia miltiorrhiza/water-soluble compounds/tanshi-nol/salvianolic acid B/bone metabolism/osteoporosis分类
医药卫生引用本文复制引用
李淑惠,梁燕龙,杨亚军,赖文秀,崔燎..丹参水溶性成分影响骨代谢的机制研究进展[J].中国药理学通报,2016,32(7):902-905,4.基金项目
国家自然科学基金资助项目（ No 81273518）；广东省科学计划项目（No 2012B060300027）；广东医学院科技创新基金项目 （）
