中国药理学通报2016，Vol.32Issue(7)：906-909,4.DOI:10.3969/j.issn.1001-1978.2016.07.005
葡萄糖转运蛋白1与肿瘤能量代谢关系的研究进展
Research progress on relationship between glucose transporter 1 and tumor energy metabolism
摘要
Abstract
The study on tumor metabolism has been gradually be-come a hot spot in recent years .A lot of proteins involved in the regulation of tumor metabolism especially the glucose transporter protein 1(GLUT1).As a key regulatory factor mediating energy metabolism within tumor cells , GLUT1 can regulate the glucose intake and maintain the basic level of metabolism in tumor cells . More importantly, the abnormal expression of GLUT1 was asso-ciated with many kinds of tumors , of which GLUT1 was used to meet the energy requirement for the fast growth of tumor .Thus GLUT1 also played a crucial role in growth , differentiation and metastasis of tumor cells and prognosis of tumors .Meanwhile , as three-dimensional crystal structure of GLUT 1 was determined , it is possible to design the small molecular inhibitors of GLUT 1, which can realize “starve to death” tumor cells.GLUT1 can be a particularly attractive target for tumor treatment and interfer-ence.The relationship between abnormal expression of GLUT 1 protein and tumor metabolism was reviewed . Moreover , the mechanism of tumor metabolism regulated by GLUT 1 protein ex-pression and treatment of cancers were discussed , which may provide references for future research and clinical treatment .关键词
肿瘤转运体-1/肿瘤代谢/葡萄糖/分子机制/特异性受体/治疗策略Key words
glucose transporter-1/tumor metabolism/glucose/molecular mechanisms/specific receptor/therapy strategies引用本文复制引用
余苏云,刘兆国,贾琦,陈力川,祝娉婷,陈文星,王爱云,陆茵..葡萄糖转运蛋白1与肿瘤能量代谢关系的研究进展[J].中国药理学通报,2016,32(7):906-909,4.基金项目
国家自然科学基金资助项目（No 81403260，81573859），中国博士后科学基金（No 2014M551639）；江苏省自然科学基金（No 1401138C）；2013年江苏高校优秀科技创新团队计划［苏教科（2013）10号文］；江苏高校品牌专业建设工程资助项目PPZY2015 A070；江苏高校中药学优势学科建设工程资助项目（PAPD）［苏政办发（2014）37号文］ （）
