中国药理学通报2016，Vol.32Issue(7)：910-914,5.DOI:10.3969/j.issn.1001-1978.2016.07.006
DNA 同源重组修复与乳腺癌的研究进展
Research progress of relationship between DNA homologous recombination repair and breast cancer
摘要
Abstract
Double-strand DNA breaks ( DSBs) are the most dele-terious events in eukaryotic cells , and there are two major path-ways for repairing them: homologous recombination ( HR ) and non-homologous DNA end joining ( NHEJ ) .BRCA1/2 proteins are key factors in HR repair pathway for DSBs and play an es-sential role in BRCA tumor suppressor network , which maintains genomic integrity and stability .Pathogenic mutations of core genes in this network may damage the DNA repair process and increase the risk of breast cancer .This review summarizes the current reports on the relationship between breast cancer suscep-tibility and mutations of the key factors in DNA HR repair asso-ciated tumor suppressor network , and aims at promoting the pre-vention, molecular diagnosis and precision treatment of the breast cancer patients with aforementioned mutations .关键词
DNA双链断裂/同源重组修复/乳腺肿瘤/易感基因/抑癌基因/BRCA/化疗Key words
DNA double-strand DNA breaks/homologous re-combination repair/breast neoplasm/susceptibility gene/tumor suppressor gene/BRCA/chemotherapy引用本文复制引用
邱宇凡,胡蕴慧,张瑾..DNA 同源重组修复与乳腺癌的研究进展[J].中国药理学通报,2016,32(7):910-914,5.基金项目
国家自然科学青年基金项目（ No 81402408）；国家科技支撑计划项目 （）
