中国药理学通报2016，Vol.32Issue(7)：956-959,4.DOI:10.3969/j.issn.1001-1978.2016.07.014
硫化氢对肾血管性高血压大鼠动脉舒张功能的调节作用
Effects of hydrogen sulfide on arterial vasodilatation function of renal hypertensive rats
摘要
Abstract
Aim To investigate the modulation effects of NaHS on arterial vasodilatation functions of renal hy-pertensive rats .Methods Two-kidney , one-c lip ( 2K1C ) renovascular hypertension was induced .Rats were randomly divided into four group:sham group , two-kidney one-clip model ( 2K1C ) group, 2KIC +NaSH( H2 S donor ) group, PPG group.The systolic blood pressure ( SBP ) was measured before the opera-tion and each week after the operation .The carotid ar-tery was collected for morphometric parameters ( outer radius, wall thickness, the radio of wall thickness to outer radius) and the tension of the carotid artery was observed with the isolated artery ring technique .Immu-nohistochemistry was used to determine the protein ex-pression of eNOS , ET-1 protein in carotid artery .Re-sults The blood pressure of 2K1C group and PPG group was higher than that of sham group ( P<0.05) . Compared with 2K1C group,the blood pressure and the rat arteria carotis communis of the radio of wall thick-ness to outer radius of 2K1C+NaHS group decreased significantly , while the relaxation of carotid artery to ACh in NaHS group increased .According to the immu-nohistochemistry results , eNOS expression was upregu-lated while ET-1 was downregulated in 2K1C +NaHS group as compared with 2K1C group.Conclusions Chronical administration of NaHS can decrease blood pressure in renovasocular hypertensive rats .The anti-hypertensive effect of H 2 S maybe associated with im-provement of the arterial functions .关键词
硫化氢/肾血管性高血压/两肾一夹/内皮依赖性/eNOS/ET-1Key words
hydrogen sulfide/renovascular hyperten-sion/2 K1 C/endothelial dependent/eNOS/ET-1引用本文复制引用
潘国聘,张小毅,李东亮,赵红岗,刘瑞丽..硫化氢对肾血管性高血压大鼠动脉舒张功能的调节作用[J].中国药理学通报,2016,32(7):956-959,4.基金项目
国家自然科学基金资助项目 （）
