中国药理学与毒理学杂志2016，Vol.30Issue(7)：754-761,8.DOI:10.3867/j.issn.1000-3002.2016.07.008
中草药有效成分对神经可塑性的影响及机制研究进展
Research progress in effects and mechanisms of active components of Chinese herbal medicine on neural plasticity
摘要
Abstract
Emotional and cognitive disorders (EACD),such as depression and anxiety,have become very common in today′s society,seriously affecting human lives and health. Neural plasticity can reflect the anti-stress ability of the nervous system to the internal and external stimulation,and is capable of dynamic changes in structure or function to adapt to environmental changes,as is often manifested in the process of compensation and repair of nerve injuries. EACD is often accompanied by macroscopic and cellular morphological changes in brain tissues and functions. Thus,studies on the mechanisms of neural plasticity will contribute to the treatment of EACD. In this paper ,the role of neural plasticity in the active components of Chinese herbal medicine(ACCHM) is reviewed. The effects of ACCHM on 5-hydroxytryptamine(5-HT)system,and the antioxidant activities and neurotrophic effects of ACCHM are described. ACCHM can affect neural plasticity,playing a neuroprotective role by improving 5-HT levels,reducing oxidative stress in brain cells,and increasing the expression of brain derived neurotrophic factor(BDNF). In summary,one ACCHM could affect neural plasticity through one or more mechanisms. There are interactions between different mechanisms of the same ACCHM. Different ACCHM can play a synergistic effect on the enhancement of neural plasticity because of their different mechanisms.关键词
中草药/神经可塑性/5-羟色胺/抗氧化剂/神经营养Key words
Chinese herbal/neural plasticity/5-hydroxytryptamine/antioxidants/neuronutrition分类
医药卫生引用本文复制引用
林蒙蒙,张美玲,王小军,李功华..中草药有效成分对神经可塑性的影响及机制研究进展[J].中国药理学与毒理学杂志,2016,30(7):754-761,8.基金项目
浙江省中西医结合学会临床药学科研专项基金（2014LY2D013）；浙江省自然科学基金（LQ14H280003）@@@@The project supported by Clinical Pharmacy Research Special Found of Zhejiang Provincical Associa-tion of Chinese Integrative Medicine（2014LYZD013）；and Natural Science Foundation of Zhejiang Province （）
