中国药理学与毒理学杂志2016，Vol.30Issue(7)：770-776,7.DOI:10.3867/j.issn.1000-3002.2016.07.010
Rab蛋白调控葡萄糖转运蛋白4转运机制的研究进展
Role of Rab proteins in glucose transporter 4 translocation:research advances
摘要
Abstract
Insulins maintain blood glucose homeostasis in the body by stimulating glucose uptake into muscle and adipose tissues through glucose transporter type 4 (GLUT4)translocation. Recent studies have showed that Rab proteins,as a key regulatory factor for the translocation of GLUT4 to the cell membrane,participate in the formation,translocation and fusion of GLUT4 vesicles. This paper describes several types Rab proteins and the Rab GTPase activating protein,protein kinase B substrate of 160 kU(AS160)in terms of regulatory mechanisms for GLUT4 translocation. Studies on the translocation mechanism by which GLUT4 is regulated by Rabs aim to explain the mechanism of insulin resistance in type 2 diabetes,and provide a new approach to diabetes.关键词
葡萄糖转运体4型/胰岛素类/Rab蛋白/胰岛素受体底物蛋白质类Key words
glucose transporter type 4/insulins/Rab proteins/insulin receptor substrate proteins分类
医药卫生引用本文复制引用
欧丽婷,许迎科,李汉兵..Rab蛋白调控葡萄糖转运蛋白4转运机制的研究进展[J].中国药理学与毒理学杂志,2016,30(7):770-776,7.基金项目
浙江省自然科学基金（LY14H310003），浙江省自然科学基金（LY13C050001）；教育部博士点基金（20130101120172）@@@@The project supported by Natural Science Foundation of Zhejiang Province（LY14H310003）；Natural Science Foundation of Zhejinag Province（LY13C050001）；and Doctoral Fund of Ministry of Education of China （）
