中国药理学与毒理学杂志2016，Vol.30Issue(7)：777-783,7.DOI:10.3867/j.issn.1000-3002.2016.07.011
外泌体在肿瘤发生中的调节作用研究进展
Regulation of exosomes in tumor:research progress
摘要
Abstract
Exosomes are extracellular nanoparticles secreted by multiple types of cells,which are enriched for some bioactive molecules,such as proteins,messcge RNA(mRNA),micro RNA(miRNA), DNA and lipid. These molecules are documented to be involved in the process of intercellular material exchange and signal communication,thus affecting the function of cells. Also,exosomes are considered to participate in tumor angiogenesis,cancer progression and metastasis,but the mechanism remains obscure. Exosomes are of great value for the diagnosis and treatment of tumor. The correlations between exosomes and tumorigenesis and tumor metastasis as well as their clinical applications are summarized in this review.关键词
外泌体/肿瘤/肿瘤诊断/生物标志物Key words
exosome/tumor/tumor diagnosis/biomarkers分类
医药卫生引用本文复制引用
吕程程,朱运峰..外泌体在肿瘤发生中的调节作用研究进展[J].中国药理学与毒理学杂志,2016,30(7):777-783,7.基金项目
国家高技术研究发展计划项目（2011AA02A110）@@@@The project supported by National High Technology Research and Development Program of China （）
