中国药理学与毒理学杂志2016，Vol.30Issue(7)：784-789,6.DOI:10.3867/j.issn.1000-3002.2016.07.012
受体型酪氨酸激酶RON及其在恶性肿瘤发生发展中的作用研究进展
Role of tyrosine kinase receptor RON in tumor growth and metastasis:research progress
摘要
Abstract
Recepteur d′origine Nantais(RON),a tyrosine kinase receptor ,is a growth factor receptor belonging to the proto-oncogene met family and has been proved to display abnormal expres⁃sion in many types of tumors. The RON receptor is activated by binding to the ligand macrophage stim⁃ulating protein,overexpression of the receptor,variants of the proto-oncogene and by point mutations of the kinase region. The downstream transduction of RON by mitogen-activated protein kinases and phosphoinositide3-kinase signaling pathways can help regulate the proliferation,apoptosis,migration and invasion of tumor cells. A better understanding of the mechanisms and related signaling pathways of RON activation in tumor progress and development will provide more information for the RON-based target therapy.关键词
酪氨酸激酶/RON/肿瘤/靶向治疗Key words
tyrosine kinase receptor/RON/cancer/target therapy分类
医药卫生引用本文复制引用
马琪,虞碧霞,陈俊丰,程跃..受体型酪氨酸激酶RON及其在恶性肿瘤发生发展中的作用研究进展[J].中国药理学与毒理学杂志,2016,30(7):784-789,6.基金项目
国家自然科学基金（81272828）；浙江省医药卫生科技计划项目（2016KYB263）；宁波市自然科学基金（2015A610224）@@@@The project supported by National Natural Science Foundation of China（81272828）；Zhejiang Pro-vincial Foundation for Medical and Health Sciences （2016KYB263）；and Ningbo Natural Science Foundation （）
