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免疫抑制剂治疗系统性红斑狼疮患者淋巴细胞亚群失调的疗效观察

黎志锋 陈国强 张红卫 林嘉鸿

中国药物经济学2016,Vol.11Issue(7):47-49,3.
中国药物经济学2016,Vol.11Issue(7):47-49,3.DOI:10.12010/j.issn.1673-5846.2016.07.014

免疫抑制剂治疗系统性红斑狼疮患者淋巴细胞亚群失调的疗效观察

The Effect of Immunosuppressive Agents on Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus

黎志锋 1陈国强 1张红卫 1林嘉鸿1

作者信息

  • 1. 佛山市第一人民医院,广东佛山 528000
  • 折叠

摘要

Abstract

Objective to investigate the effect of immunosuppressive agents on the lymphocyte subsets imbalance in patients with systemic lupus erythematosus (SLE).Methods That the July January 2014 to 2015,Foshan City the first people's Hospital of 60 cases of SLE patient chooses as the research object,which was not in treatment and the immune inhibitors in the treatment of patients with 30 cases in each.At the same time,the selection of healthy in the same period,60 patients as control group.The SLE cels,B cels and natural kiler (NK) cels in peripheral blood were detected by flow cytometry.The expression levels of interferon gamma (IFN-γ) and interleukin 4 (IL-4) in serum were detected by ELISA.Results SLE patients CD3+CD4+Th cel ratio,Th cel /Ts cels,CD3-CD16+CD56+NK cel proportion of were significantly lower than those of the control group CD3+CD8+Ts cels,CD3-CD19+B cel ratio was significantly higher than that of the control group,differences were statisticaly significant(P<0.05);compared with the control group,the SLE patients who serum IFN gamma levels,ratio of IFN-γ/IL-4 were significantly increased,and the level of IL-4 decreased significantly,the differences were statisticaly significant(P<0.05);the use of immunosuppressive therapy,a marked increase in the proportion of patients with CD3+CD4+ T cels,CD3-CD19+B cel ratio was significantly decreased,Th cels /Ts cel ratio significantly higher than untreated group,diferences were statisticaly significant(P<0.05). Conclusion SLE patients are often treated with immunosuppressive agents,effectively regulate and change th cel /Ts cel proportion and the decline in the number of B cels,and peripheral blood lymphocyte subsets in proportion to the normal direction adjustment,effectively improve the lymphocyte subsets in patients with disorders of.

关键词

系统性红斑狼疮/淋巴细胞亚群/干扰素-γ/白细胞介素-4

Key words

Systemic lupus erythematosus/Lymphocyte subsets/IFN-γ/IL-4

分类

医药卫生

引用本文复制引用

黎志锋,陈国强,张红卫,林嘉鸿..免疫抑制剂治疗系统性红斑狼疮患者淋巴细胞亚群失调的疗效观察[J].中国药物经济学,2016,11(7):47-49,3.

中国药物经济学

1673-5846

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