中国医学创新2016，Vol.13Issue(19)：14-17,4.DOI:10.3969/j.issn.1674-4985.2016.19.004
转录因子TBX3在小鼠胚胎动脉囊及弓动脉发育过程中的表达
Expression of the Transcription Factor TBX3 during Development of Mouse Embryonic Aortic Sac and Arch Arteries
摘要
Abstract
Objective:To explore the relationship between transcription factor TBX3 (T-box transcription factor3) and the development of aortic sac in the during early development mouse embryo.Method:Serial paraffin sections of mouse embryonic hearts form embryonic 9 days to 12 days(E9-E12) were stained with antibodies against T-box transcription factor3(TBX3),islet-1(ISL-1) and α-smooth muscle actin (α-SMA )by the immunohistochemical method.Result:At embryonic 9 days,TBX3 positive cells gathered in the pulmonary endoderm.At embryonic 10 days,we could observe that there TBX3 positive cells at the communication between aortic sac and third arch artery.At embryonic 11 days,communication between the fourth and sixth arch arteries observed TBX3 positive expression.At embryonic 12 days,TBX3 positive expression was mainly focused on pharyngeal mesenchymal.Conclusion:The cardiac conduction system of positive precursor cells TBX3 involved in aortic sac and arch arteries morphogenesis.关键词
动脉囊/转录因子TBX3/胰岛素增强子结合蛋白/免疫组化/小鼠Key words
Aortic sac/Transcription factor TBX3/Islet-1/Immunohistochemistry/Mouse引用本文复制引用
许智慧,杨艳萍,王晶晶,宋励,师亮,景雅..转录因子TBX3在小鼠胚胎动脉囊及弓动脉发育过程中的表达[J].中国医学创新,2016,13(19):14-17,4.基金项目
国家自然科学基金资助项目 （）
