摘要
Abstract
Objective:To explore the curative effect on treatment of severe COPD patients in stable phase by inhalation of Tiotropium Bromide combined with Salmeterol/Fluticasone Propionate.Method:Severe COPD patients in stable phase were selected, and were randomly divided into group A of 67 cases and group B of 71 cases.Based on health education,patients in group A were treated by Salmeterol/Fluticasone Propionate,and patients in group B were treated by Tiotropium Bromide combined with Salmeterol/Fluticasone Propionate.Two groups’ lung function,6MWT,SGRQ scores,blood gas and serum CRP levels were compared before and after treatment,curative effects of two groups were evaluated,COPD exacerbations and adverse reactions of two groups were recorded.Result:after 12 weeks treatment,two groups’ FEV1,FVC,FEV1%,6MWT,PaO2 levels were all increased,while SGRQ scores,PaCO2 and serum CRP levels were all decreased, combined with before treatment,the differences were statistically significant(t=3.76~7.09,P<0.05 orP<0.01).The FEV1,FVC, FEV1%,6MWT and PaO2 levels of group B were all higher than that in group A,SGRQ scores,PaCO2 and serum CRP levels of group B were all lower than that in group A,the differences were statistically significant(t=3.67~5.00, P<0.05).Total effective rate in group A and B were respectively 77.61% and 92.96%,the difference was statistically significant( χ2=6.55,P<0.05).COPD exacerbation rates in group A and B were respectively 14.93%and 4.23%,the difference was statistically significant( χ2=4.63,P<0.05).Except for 1 case sinus tachycardia and 1 case thirst,there was no other significant adverse reactions.Conclusion:It has good intervention effect on treatment of severe COPD patients in stable phase by inhalation of Tiotropium Bromide combined with Salmeterol/Fluticasone Propionate,improves lung function,biochemical and inflammation and other indicators,also improves exercise tolerance and quality of life,reduces exacerbations frequency,and has high safety,it is better than single drug’s effect.So it has a certain guidance and reference on intervention of severe COPD patients in stable phase.关键词
慢性阻塞性肺疾病/稳定期/噻托溴铵/舒利迭Key words
Chronic obstructive pulmonary disease/Stable phase/Tiotropium Bromide/Seretide
