中国医学创新2016，Vol.13Issue(20)：1-4,4.DOI:10.3969/j.issn.1674-4985.2016.20.001
骨肉瘤患者细胞侵袭相关IL-6、IL-12血清水平检测的临床意义
Clinical Significance of Detection of Cell Invasion Related IL-6 and IL-12 Serum Levels in Osteosarcoma Patients
摘要
Abstract
Objective:To explore the difference of serum IL-6 and IL-12 levels between the patients with osteosarcoma and healthy individuals,as well as its clinical signifcance.Method:By ELISA,the concentration of serum IL-6 and IL-12 levels were measured in 160 patients with osteosarcoma(osteosarcoma group) and 250 healthy individuals (controls group).Differences between serum IL-6 and IL-12 levels were compared and analyzed its correlation.The relationship between serum IL-6 and IL-12 levels and the incidence and progression of osteosarcoma were investigated.Result:The levels of serum IL-6 was significantly higher in the osteosarcoma group than in the control group(P<0.01),the level of serum IL-12 was significantly lower in the case group than in the controls group (P<0.01).Serum IL-12 levels in stages Ⅲ-Ⅳ were lower than those in stages Ⅰ-Ⅱ of osteosarcoma (P<0.05).Patients with metastasis had higher IL-12 levels than those without metastasis (P<0.05). No associations were found between IL-6 and IL-12 levels(P>0.05).Conclusion:This study indicates that serum IL-6 and IL-12 levels abnormal expression in osteosarcoma patients. IL-6 and IL-12 may play the role of immunoregulation in the pathogenesis of osteosarcoma,the lower serum IL-12 levels may be associated with development and progression of osteosarcoma.关键词
骨肉瘤/白细胞介素6/白细胞介素12Key words
Osteosarcoma/Interleukin-6/Interleukin-12引用本文复制引用
陆潞,廖品琥,谢克恭,陆敏安,卢贤哲,黄可,王俊利,韦叶生,唐毓金..骨肉瘤患者细胞侵袭相关IL-6、IL-12血清水平检测的临床意义[J].中国医学创新,2016,13(20):1-4,4.基金项目
国家自然科学基金资助项目（81260315）；广西自然科学基金项目（2012GXNSFAA053169）；百色市科学研究与技术开发项目 （）
