中国医学创新2016，Vol.13Issue(20)：36-38,3.DOI:10.3969/j.issn.1674-4985.2016.20.009
右美托咪定对丙泊酚的水相浓度的影响
The Effects of Dexmedetomidine on the Concentration of Propofol in Aqueous Phase
摘要
Abstract
Objective:To use high performance liquid chromatography (HPLC)to determinate the Dexmedetomidine mixed with Propofol injection aqueous phase concentration and investigate the effect of Dexmedetomidine mechanism of Propofol injection pain.Method:Propofol injection will be tested according to the concentration of Dexmedetomidine were divided into three group,each group had 5 cases.Group A was simply Propofol injection group,group B was given Propofol injection with Dexmedetomidine 0.75μg/mL,group C was given Propofol injection with Dexmedetomidine 1.25μg/mL.The aqueous phase free concentration of Propofol in each sample was determined by HPLC after the reverse dialysis method used in the water phase and the aqueous phase concentration of the three groups were compared.Result:The highest aqueous phase concentration was group A,the lowest aqueous phase concentration was group C,there were significant differences between three groups in the aqueous phase concentration(P<0.05).Conclusion:Dexmedetomidine alleviates the propofol injection pain likely through decreasing the concentration of Propofol in aqueous phase of injection solution.关键词
右美托咪定/丙泊酚/注射痛/水相浓度/高效液相色谱法Key words
Dexmedetomidine/Propofol/Injection pain/Aqueous phase concentration/High performance liquid chromatography引用本文复制引用
杨柳,曹殿青,梁艳丽,郑荣..右美托咪定对丙泊酚的水相浓度的影响[J].中国医学创新,2016,13(20):36-38,3.基金项目
广东省科学技术厅科技基金 （）
