中国医院用药评价与分析2016，Vol.16Issue(7)：899-901,3.DOI:10.14009/j.issn.1672-2124.2016.07.013
临时配制的对乙酰氨基酚混悬液的稳定性与分剂量研究Δ
Research on Stability and Divided Dose of Extemporaneous Paracetamol SuspensionΔ
摘要
Abstract
OBJECTIVE:To probe into the stability and divided dose of extemporaneous paracetamol suspension prepared by single syrup and pure water as diluents .METHODS: Paracetamol suspension tablets were crushed into powder , and simple syrup and pure water were added .Meanwhile , stability test and divided dose test were respectively conducted on the paracetamol suspension , the accuracy of the divided dose at 0 , 4 , 8 , 24 h and the stability of the suspension stored at 72 hours afterward at room temperature (25 ℃) and the refrigerator (2-10 ℃) were evaluated. RESULTS:In the stability test , concentration of the two mixed suspension stored at 72 hours afterward were between 98%-102%of initial concentration;in the 24 h divided dose test , there were no significant difference in simple syrup suspension at different time points ( P >0.05 ) , but there were significant difference in pure water suspension at different time points ( P<0.05 ) .CONCLUSIONS: The stability of paracetamol powder with simple syrup and pure water stored at least 72 hours at room temperature ( 25 ℃) and the refrigerator ( 2-10 ℃) was relatively good; yet drugs in simple syrup are more accurate than those in aqueous solution in divided dose test in both environments .关键词
对乙酰氨基酚/稳定性/分剂量Key words
Paracetamol/Stability/Divided dose分类
医药卫生引用本文复制引用
刘丽利,张建民,姬志强,石磊..临时配制的对乙酰氨基酚混悬液的稳定性与分剂量研究Δ[J].中国医院用药评价与分析,2016,16(7):899-901,3.基金项目
济南军区联勤部科研项目 （）
