中华耳科学杂志2016，Vol.14Issue(2)：167-169,3.DOI:10.3969/j.issn.1672-2922.2016.02.008
水杨酸钠对大鼠下丘多巴胺水平影响的研究
Effects of salicylate on dopamine levels in rat inferior colliculus
摘要
Abstract
Objective To investigate dopamine level changes in the inferior colliculus induced by salicylate and the role of dopamine in the mechanisms of tinnitus. Methods In an animal model of salicylate-induced tinnitus, we employed microdialysis combined with electrochemical methodologies to monitor changes of dopamine in rat inferior colliculus. Re-sults Salicylate produced significant decrease in dopamine levels in the inferior colliculus, to a minimum of 49 ± 9%of base-line around 3 h post injection, followed by a return to the baseline by the end of the fifth hour. In contrast, saline did not pro-duce any clear changes. Conclusion The decrease of dopamine in the inferior colliculus may be involved in the generation of tinnitus. Our in vivo data provide direct evidence of the important roles the dopaminergic system plays in the generation of tinnitus.关键词
水杨酸钠/耳鸣/下丘/多巴胺/微透析/高效液相色谱Key words
sodium salicylate/tinnitus/inferior colliculus/dopamine/microdialysis/high performance liquid chroma-tography分类
临床医学引用本文复制引用
刘俊秀,刘轶君,毛兰群,李学佩,马芙蓉..水杨酸钠对大鼠下丘多巴胺水平影响的研究[J].中华耳科学杂志,2016,14(2):167-169,3.基金项目
国家自然科学基金项目(30500556、21372020）和北京市自然科学基金项目（7082100、7112144）联合资助This research is financially supported by the NSF of China (30500556，21372020）and NSF of Beijing(7082100,7112144) （30500556、21372020）和北京市自然科学基金项目（7082100、7112144）联合资助This research is financially supported by the NSF of China (30500556，21372020）and NSF of Beijing(7082100,7112144）
