中华耳科学杂志2016，Vol.14Issue(2)：223-228,6.DOI:10.3969/j.issn.1672-2922.2016.02.020
鼠神经生长因子在突发性耳聋中的疗效观察
Mouse nerve growth factor for treatment of sudden deafness
王淑芳 1张莉 1张雯雯 2耿彬2
作者信息
- 1. 内蒙古医科大学附属医院
- 2. 内蒙古医科大学
- 折叠
摘要
Abstract
Objective To investigate the efficacy of mouse nerve growth factor combined with Ginkgo biloba ex-tracts, vinpocetine and dexamethasone in the treatment of sudden deafness, in order to improve treatment of sudden deaf-ness. Methods Eighty four patients, treated in our department between January 2013 and June 2014, were randomly divid-ed into an experimental group (mouse nerve growth factor+Ginkgo biloba extracts, vinpocetine and dexamethasone) and a control group (Ginkgo biloba extracts, vinpocetine and dexamethasone only) (n=42 in each group). Patients in each group were characterized based on patterns of hearing loss, i.e. high frequency loss, low frequency loss and pan-frequency loss. Treatment results were compared between the two groups, including improvement of hearing and concurrent symptoms. Re-sults 1. The rate of total effectiveness in the experimental group was 80.95%, higher than the control group (X2=6.323, P=0.028);2. Hearing improvement was greater in the experimental group (23.87 ± 15.50 dB) than in the control group (15.4 ± 13.84 dB);3. The rate of total effectiveness was the highest for low frequency hearing loss (P<0.05);4. The rate of tinnitus was higher with high frequency hearing loss and lower with low frequency hearing loss (P<0.05). In this study, the total ef-fective rate was the highest in patients with low frequency hearing loss and tinnitus (P<0.05). The overall effective rate for all types of hearing loss with tinnitus was higher in the experimental group than in the control group (P<0.05). Conclusion (1) Mouse nerve growth factor combined with Ginkgo biloba extracts, vinpocetine and dexamethasone seems to be effective in treating various types of sudden deafness. (2) It seems to be most effective for low frequency hearing loss. (3) It is effec-tive in all types of sudden deafness with tinnitus, of which high frequency loss shows the highest incidence and low frequen-cy loss the lowest incidence. Treatment effects appear better for low frequency sudden hearing loss with tinnitus.关键词
鼠神经生长因子/银杏叶提取物/长春西汀/激素/突发性/耳聋/耳鸣Key words
mouse nerve growth factor/Ginkgo biloba extract/vinpocetine/dexamethasone/sudden/deafness/tin-nitusand分类
医药卫生引用本文复制引用
王淑芳,张莉,张雯雯,耿彬..鼠神经生长因子在突发性耳聋中的疗效观察[J].中华耳科学杂志,2016,14(2):223-228,6.
