中华耳科学杂志2016，Vol.14Issue(3)：414-419,6.DOI:10.3969/j.issn.1672-2922.2016.03.021
氢气选择性抗氧化作用在内耳急性损伤防治中的作用
Selective Antioxidant Effect and Protective Role of Hydrogen against Acute Inner Ear Injury
摘要
Abstract
Excessive Reactive Oxygen Species (ROS) in noise-induced or drug-induced hearing loss causes inner ear serious damage. Recent studies have shown that hydrogen, which acts as a safe and effective antioxidant by reaching the re-active area quickly and reacting with strong oxidizing ROS, can alleviate oxidative stress effectively. Selective antioxidant effect by hydrogen may be related to reducing oxidative stress, decreasing cell apoptosis and regulating cell signaling path-ways. Studying antioxidant effects by hydrogen provides a new approach to the treatment of inner ear acute injury. The pres-ent review summarizes possible mechanisms of hydrogen in preventing inner ear from acute injury.关键词
噪声性聋/氧化应激/抗氧化/氢气Key words
Noise-induced Hearing Loss/Oxidative Stress/Antioxidant/Hydrogen分类
医药卫生引用本文复制引用
蔡蔚然,周义德..氢气选择性抗氧化作用在内耳急性损伤防治中的作用[J].中华耳科学杂志,2016,14(3):414-419,6.基金项目
This work was supported by grants from the National Natural Science Foundation of China (No.81170913), the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (2010) and the Ministry of Human Resources and So-cial Security of China(2009).基金项目国家自然科学基金面上项目（81170913）；国家人力资源和社会保障部留学回国人员科研启动基金（2009年）；国家教育部留学回国人员科研启动基金 （No.81170913）
