中华耳科学杂志2016，Vol.14Issue(3)：431-435,5.DOI:10.3969/j.issn.1672-2922.2016.03.024
中耳胆脂瘤动物模型的建立及研究进展
Establishment of animal models of middle ear cholesteatoma and relevant research
摘要
Abstract
The pathogenesis of middle ear cholesteatoma remains unclear and there is no effective nonsurgical thera-py. Animal models are very important for studying pathogenesis, prevention and treatment of middle ear cholesteatoma. Common animal models involve ligation of the external ear canal, eustachian tube blocking, chemical injection into the mid-dle ear, autologous skin graft implantation plus intratympanic injection of Pseudomonas aeruginosa, and in vivo electropora-tion for Flag-hKGF vector transfection. In this paper, we reviewed current animal models of middle ear cholesteatoma in or-der to provide an experimental basis for further study of the pathogenesis (e.g. retraction pocket theory, immigration theory, basal cell hyperplasia theory), prevention and treatment of middle ear cholesteatoma.关键词
胆脂瘤/中耳/动物模型Key words
Cholesteatoma/Middle ear/Animal model分类
医药卫生引用本文复制引用
王晓丽,谢淑敏,刘伟,任基浩,谢鼎华..中耳胆脂瘤动物模型的建立及研究进展[J].中华耳科学杂志,2016,14(3):431-435,5.基金项目
国家自然科学基金 （）
