中华骨质疏松和骨矿盐疾病杂志2016，Vol.9Issue(2)：129-135,7.DOI:10.3969/j.issn.1674-2591.2016.02.005
2型糖尿病患者肌少症的相关因素
Relative factors to sarcopenia in T2DM patients
吴佳佳 1王炜 1祝捷 1吴玉洁 1陈超 1邢学农1
作者信息
- 1. 230001 合肥，安徽医科大学附属安徽省立医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the relationship between sarcopenia , gender, age, 25-hydroxyvitamin D (25OHD) level and diabetic duration in type 2 diabetes mellitus (T2DM) patients.Methods Sixty controls, one hun-dred thirty-two patients with T2DM were enrolled in the study .All the subjects underwent body composition measurement by dual-energy X-ray absorptiometry (DXA), and the serum 25OHD level were measured by electrochemiluminescence method.Sarcopenia was diagnosed by the Baumgartner diagnostic criteria .The prevalence of sarcopenia in T2DM group and the control group was compared , and in different gender respectively .The subjects in the two groups were divided in-to five subgroups according to age .Afterwards, these subgroups were divided into vitamin D severe deficiency ( <10 ng/mL), deficiency (≥10 and <20 ng/mL), insufficiency (≥20 and <30 ng/mL) and sufficiency group (≥30 ng/mL).T2DM group was divided into a-e groups according to the diabetic duration .The prevalence of sarcopenia in each group was compared .Results Compared with the control group (11.7%), the prevalence of sarcopenia in T2DM group (24.2%) was higher.The prevalence of sarcopenia in men was higher than in women ( T2DM group: 32.8%/15.4%; the control group: 23.1%/2.9%, P<0.05 ) .The prevalence of sarcopenia in subjects older than 80 years old (T2DM group: 50.0%, the control group: 42.9%) was the highest, and the subjects with sarcopenia was older than those without sarcopenia (P<0.05).The prevalence of sarcopenia in vitamin D severe deficiency group (T2DM group: 41.7%; the control group: 30.0%) was higher, and the 25OHD level of subjects with sarcopenia was lower than those without sarcopenia ( P<0.05 ) .The prevalence of sarcopenia in diabetic duration more than 20 years group (61.1%) was higher, and the diabetic duration of subjects with sarcopenia was longer than those without sarcopenia (P<0.05).Conclusion Aging, gender, T2DM and diabetic duration are risk factors for sarcopenia .Low serum 25OHD level may be related to sarcopenia .关键词
2型糖尿病/25羟基维生素D/性别/年龄/肌少症Key words
type 2 diabetes mellitus/25-hydroxyvitamin D/gender/age/sarcopenia分类
医药卫生引用本文复制引用
吴佳佳,王炜,祝捷,吴玉洁,陈超,邢学农..2型糖尿病患者肌少症的相关因素[J].中华骨质疏松和骨矿盐疾病杂志,2016,9(2):129-135,7.
