浙江大学学报（理学版）2016，Vol.43Issue(4)：420-425,450,7.DOI:10.3785/j.issn.1008-9497.2016.04.008
A 2A腺苷受体拮抗剂中间体与抗结剂合成方法研究
Synthesis of an important intermediate of antagonists of the human A2A adenosine receptor
屠美玲 1俞卫平 2冯涛 2贾继宁 1张云 1张建庭1
作者信息
- 1. 浙江工业大学化学工程与材料学院，浙江杭州310014
- 2. 杭州职业技术学院，浙江杭州310018
- 折叠
摘要
Abstract
Antagonism of the human A2A receptor has been implicated as a point of therapeutic intervention in the alleviation of the symptoms associated with Parkinson's disease .That is to say ,at least in part ,this kind of antago‐nists can improve the sensitivity of the dopaminergic neurons to the residual ,and deplete levels of striatal dopamine . Herein ,we reported a novel synthesis strategy of an important intermediate (4‐chloro‐1H‐benzo[d][1 ,2 ,3]triazol‐6‐amine) of antagonists of the human A2A adenosine receptor .Additionally ,we had also prepared the adenosine receptor 8 .关键词
帕金森综合征/A2A腺苷受体拮抗剂/合成Key words
Parkinson's disease/antagonist of human A2A adenosine receptor/synthesis分类
化学化工引用本文复制引用
屠美玲,俞卫平,冯涛,贾继宁,张云,张建庭..A 2A腺苷受体拮抗剂中间体与抗结剂合成方法研究[J].浙江大学学报（理学版）,2016,43(4):420-425,450,7.
