临床口腔医学杂志2016，Vol.32Issue(8)：451-454,455,5.DOI:10.3969/j.issn.1003-1634.2016.08.002
骨修复材料 HAPw／n-ZnO 抗感染效果的实验研究
Experimental study on anti-infection effect of bone repair material HAPw/n-ZnO
摘要
Abstract
Objective:Anti-infection effect of HAPw/ZnO composite material on infected bone defect through animal test was observed.Method:Circular bone defect was made on the left rear lateral condyle of femur of 24 SD rats(220-250 g of either sex),where the S.aureus solutions were sent(1 ×104 CFU/ml).After two weeks,the rats were divided into experiment group ( n =14 ) and a blank group ( n =7 ) randomly.Both of the groups did debridement on the bone defect area,however,only the experiment group were further implanted the bone repairing material.The rats were executed within 2 weeks after surgery and then,tissue slice and bacterio-logical examination were carried out.Results:In contrast with the blank comparison group,the experiment group showed certain bacteriostatic and anti-infection effect,especially for HAPw/ZnO.Conclusion:HAPw/ZnO com-posite material can inhibit the growth of S.aureus and control the infection of bone defect.关键词
人工骨修复材料/HAPw/n-ZnO/感染性骨缺损/抗感染Key words
Artificial bone repair materials/HAPw/ZnO/Infected bone defect/Anti-infection分类
医药卫生引用本文复制引用
代宏伟,张文云,陈庆华,袁艳波,杨立斗..骨修复材料 HAPw／n-ZnO 抗感染效果的实验研究[J].临床口腔医学杂志,2016,32(8):451-454,455,5.基金项目
国家自然科学基金项目 （）
