临床神经外科杂志2016，Vol.13Issue(4)：245-248,251,5.DOI:10.3969/j.issn.1672-7770.2016.04.002
非典型脑膜瘤的临床分析
Clinical analysis of atypical meningioma
摘要
Abstract
Objective To investigate the diagnosis , treatment and prognostic factors of atypical meningiomas .Methods The clinical data of 89 patients with atypical meningioma who were treated at Beijing Tiantan Hospital Affiliated to Capital Medical University from 2001 to 2011 were analyzed retrospectively .Statistics were calculated using the log-rank method and Cox proportional hazards model , and reviewing related literatures to analyze the characteristics , treatment and prognosis of the disease .Results Among 89 atypical meningiomas , total resection was achieved in 40 patients.40 patients underwent radiotherapy after surgery .The median progression-free survival (PFS) was 72.6 month.(2-102 months) .The progression-free survival rate and overall survival rate of 2 year and 5 year were 74.5%,67.5% and 93.6%,89.1% respectively.On univariate analyses, secondary tumor,female,paresis and KPS score less than 80 will increase the risk of recurrence(P<0.05).On multivariate analyses, secondary tumor,paresis will increase the risk of recurrence ( P <0 .05 ) .KPS score more than 80 was a beneficial factor for OS ( P <0 .05 ) . Conclusions Total resection is the main procedure to improve the prognosis of atypical meningioma . Patients should receive radiotherapy after partial resection .For total resection , patients who existed the following factors were regarded as high-risk patients:initial symptoms for hemiplegia , secondary tumor,bone invasion,brain tissue invasion,high nuclear mitosis, higher MIB-1 index.Postoperative radiotherapy is recommended for patients with one or more facors mentinoned above .关键词
非典型脑膜瘤/治疗/预后Key words
atypical meningioma/treatment/prognosis分类
医药卫生引用本文复制引用
李俊驹,张超才,姜中利..非典型脑膜瘤的临床分析[J].临床神经外科杂志,2016,13(4):245-248,251,5.基金项目
海南省应用技术研发与示范推广专项任务书 （）
