临床神经外科杂志2016，Vol.13Issue(4)：296-300,5.DOI:10.3969/j.issn.1672-7770.2016.04.015
脑肿瘤切除术前后血清 S100B 蛋白水平的改变
Perioperative serum level of S100B in patients undergoing brain tumor resection
摘要
Abstract
Objective Brain tumor resection could cause brain damage and may affect patient's prognosis .It is supposed that S 100 B level may reflect the extend of brain insults .In this study , we explore how serum S100B changes perioperatively and whether it correlate with patient's clinical data (such as tumor volume , duration of operation, etc.).Method There is 30 glioma patients, 28 meningiomas and 15 acoustic tumor patients included .All patient's blood sample were collected on admission and at postoperative day 1, 3 and 7.And the patient's clinical data ( such as tumor volume , peritumor edema , grading by WHO classification , duration of operation , patient's Karnofsky Performance Scale , etc.) were recorded at the mean time .There is also 33 healthy adults from the medical examination center of the same hospital to be a control group and whose blood sample were collect just for once .We use a commercial ELISA kit to quantify serum level of S 100B. A repeated measure ANOVA is conduct to test among previous and post operative serum levels of S100B.And correlation analysis was made between serum S 100B and patients clinical data .Result The S100 B serum levels among glioma , meningioma and acoustic tumor patients has no statistically difference(P>0.05),and levels of S100B in both glioma and meningioma patients are higher than the control's(all P<0.05), except for the acoustic tumor group's.There is no difference among the three groups in perioperative change of serum S 100B ( P >0.05 ): Serum S100B levels in post operatively day 1 and day 3 has no change compared to its previous operative levels ( P>0 .05 ) , while serum S100B levels in post operatively day 7 is higher than the previous operative levels ( P<0.05).The correlation between post operative brain edema and serum S 100B is seen in the glioma patients in postoperative day 3 and 7 ( all P<0 .05 ) and between the grade of WHO classification of tumor and serum S100B is seen in glioma patients in postoperative day 1 and 3(all P<0.05).In the acoustic tumor patients , there were correlation between postoperative day 7 serum levels of S100B and surgery duration(all P<0.05), and between previous, postoperative day 3 serum levels of S100 B and acoustic tumor volume ( P<0 .05 ) .There is no any correlation in meningioma patients (P>0.05).Conclusion Serum S100B is poor in evaluating brain damage caused by intracranial resection , its post operative elevation may imply the neural repairment course after brain damage . There are some correlation among serum S 100 B and WHO grade and the extend of postoperative edema in glioma, so is among tumor volume and surgery duration in acoustic tumor .Glioma, meningioma could cause serum levels of S 100B increase which may reflect brain damage related with tumor expansive growth .关键词
血清/S100B/脑肿瘤/颅脑手术/术后脑损伤Key words
serum/S100B/brain tumor/brain surgery/perioperative/brain damage分类
医药卫生引用本文复制引用
蓝川琉,谭源福,曾湖,肖绍文,张超元,郑传华..脑肿瘤切除术前后血清 S100B 蛋白水平的改变[J].临床神经外科杂志,2016,13(4):296-300,5.基金项目
广西壮族自治区教育厅高校科研项目 （）
