山东医药2016，Vol.56Issue(29)：14-16,3.DOI:10.3969/j.issn.1002-266X.2016.29.005
卵巢癌组织细胞黏附分子1的表达变化及意义
Expression of CADM1 and its clinical significance in human ovarian carcinoma
夏芬 1胡燕玲 1李莉1
作者信息
- 1. 华中科技大学同济医学院附属武汉中心医院，武汉430014
- 折叠
摘要
Abstract
Objective To investigate the expression changes of cell adhesion molecule-1 (CADM1) in human ovari-an carcinoma and its clinical significance.Methods A total of 59 case of ovarian carcinoma tissues and matched tumor-adjacent tissues were collected.The mRNA and protein expression of CADM1 in the ovarian carcinoma tissues and matched tumor-adjacent tissues was examined by qRT-PCR, immunohistochemistry and Western blotting.The Chi-square test and Kaplan-Meier analysis was used to evaluate the correlation between CADM1 expression and clinicopathological characteris-tics or overall survival.Results The expression of CADM1 mRNA and protein in the ovarian carcinoma tissues was 0.28 ±0.12 and 1.32 ±0.23, respectively, 1.52 ±0.14 and 2.93 ±0.42 in the matched tumor-adjacent tissues, and signifi-cant difference was found between these two kinds of tissues (all P<0.05).The percentage of positive cells in the adja-cent tumor tissues (90%±5%) was significantly higher than that of the cancer tissues (10%±2%), P<0.05.The ex-pression of CADM1 was significantly associated with the FIGO stage, nodal metastasis and distant metastasis ( all P <0.05).The median survival time of patients with low expression of CADM1 (mRNA expression <0.57) was higher than that of patients with high expression (13.2 vs.24.5 months, P<0.05).Conclusion CADM1 is low expressed in the human ovarian cancer tissues.The low expression of CADM1 promotes the occurrence and development of ovarian cancer, and is related to its poor prognosis.关键词
卵巢肿瘤/细胞黏附分子1/临床病理参数/预后Key words
ovarian carcinoma/cell adhesion molecule-1/clinicopathological parameter/prognosis分类
医药卫生引用本文复制引用
夏芬,胡燕玲,李莉..卵巢癌组织细胞黏附分子1的表达变化及意义[J].山东医药,2016,56(29):14-16,3.
