同位素2016，Vol.29Issue(3)：184-192,9.DOI:10.7538/tws.2016.29.03.0184
靶向叶酸受体的正电子分子探针研究进展
PET Molecular Probes Targeting Folate Receptor
摘要
Abstract
Folic acid can combine specifically with folate receptors (FRs) which are over‐expressed on the epithelial cells of the tumor .The FRs are confirmed to be the tumor‐associated antigens that bind folate and folate conjugates with very high affinity and shuttle these bound molecules inside cells via an endocytic mechanism .The FR‐αis a tar‐get of critical value for nuclear imaging through using folate‐based radiotracers as it is expressed on several tumor types .Moreover ,employment of folate radiopharmaceuti‐cals for imaging of inflammatory diseases by targeting at FR‐βon activated macrophages holds promise as a further field of application .Based on these ,more and more resear‐ches focus on folate conjugates labeled with radionuclides for nuclear medicine imaging (including single photon emission computed tomography (SPECT ) and positron emis‐sion tomography (PET ) .These folate molecular probes are applied not only in cancer imaging but also in inflammation imaging .Hence ,folate‐based imaging agents may be <br> useful for selection of patients w ho could profit from such new therapy concepts and for monitoring response to a particular treatment .This review was focused on the prepara‐tion and preclinical biological evaluation of the molecular probes which were labeled by positron nuclides (18 F ,124I ,68Ga ,44Sc ,152 Tb) ,and the clinical application of these molecular probes were discussed .关键词
叶酸受体/分子探针/正电子发射计算机断层扫描Key words
folate receptor/molecular probe/positron emission tomography分类
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尹吉林,王成,王欣璐..靶向叶酸受体的正电子分子探针研究进展[J].同位素,2016,29(3):184-192,9.基金项目
中国博士后科学基金 （）
