中国组织工程研究2016，Vol.20Issue(34)：5076-5081,6.DOI:10.3969/j.issn.2095-4344.2016.34.010
生物可吸收材料在关节骨折内固定中的生物相容性
Biocompatibility of abioabsorbable material in the internalfixation of articular fractures
谢阳江 1陈恩涛 1吴波 1敖俊2
作者信息
- 1. 贵州省六盘水市水矿控股集团总医院骨一科，贵州省六盘水市 553000
- 2. 遵义医学院附属医院骨科，贵州省遵义市 563100
- 折叠
摘要
Abstract
BACKGROUND:In recent years, poly-L-lactic acid (PLLA)/polylactic acid copolymer (PLGA)/hydroxyapatite (HAP) composite bioabsorbable material hasachived desired effectin articular fractures.
<br> OBJECTIVE:To investigate the biocompatibility of PLLA/PLGA/HA bioabsorbable material in the internal fixation of articular fractures.
<br> METHODS:In vivoexperiment: 22 New Zealand rabbits were enroled to prepare ankle fracture models, and were then randomly divided into two groups, including composite material group fixed with PLLA/PLGA/HA bioabsorbable material, and metal material group fixed with metal stent. Therapeutic effects and complications were observed at 7days after surgery.In vitroexperiment: PLLA/PLGA/HA bioabsorbable material was co-cultured with MG-63 cels to observe the cel proliferation and adhesion.
<br> RESULTS AND CONCLUSION:In thein vitroexperiment,nine rabbits healed wel, and two rabbits appeared to havecomplications in the mental material group; rabbits in the composite material group healed wel without any complications.In thein vitroexperiment:fusiform-shapedcelsaladhered to the compositestent after 1 day of incubation;the number of cels began to increase showing the strong growth ability,and in a tight and regular arrangementat 3 days after incubation; the cytotoxicity was grade 0 or 1 within 1-7 days of incubation.At 3 daysof co-culture, fusiform or polygonal cels appeared on the composite material,and these interconnectdecels extended wel, andmoreover,the frizz partson thecel surface grew into thecompositematerial, displaying a good adherence. To conclude, as a new bioabsorbable material, PLLA/PLGA/HAexhibits a good biocompatibility.关键词
生物材料/材料相容性/复合生物可吸收材料/关节骨折/内固定/生物相容性/生物可吸收性/替代材料分类
医药卫生引用本文复制引用
谢阳江,陈恩涛,吴波,敖俊..生物可吸收材料在关节骨折内固定中的生物相容性[J].中国组织工程研究,2016,20(34):5076-5081,6.
