中国组织工程研究2016，Vol.20Issue(34)：5149-5154,6.DOI:10.3969/j.issn.2095-4344.2016.34.021
组织工程血管支架材料的研究与进展
Tissue-engineered vascular scaffold materials
摘要
Abstract
BACKGROUND:Tissue-engineered vascular scaffold materials havebeendeveloped from pure natural materials to degradable composite materials and nano polymer materials, andthepreparation method has alsobeendeveloped from the manual technology to the rapid proto-typing technology. <br> OBJECTIVE:To clarify the advantages and disadvantages, application and research hotspots of different tissue-engineered vascular scaffold materials, and to find a suitable scaffold material for clinical treatment. <br> METHODS:The first author retrieved databases of PubMed,CNKI and CqVip for relevant articles about tissue-engineered vascularscaffolds published from 1985 to 2015. The key words were “tissue engineering, tissue engineered, blood vessel, vascular, scaffold” in English and Chinese, respectively.In accordance with the inclusion and exclusion criteria, 36 articles were reviewed. <br> RESULTS AND CONCLUSION:Non-degradable materials are mainly used to construct largediameter tissue-engineered blood vessels.Natural biomaterials have good biocompatibility, which can provide necessarysignals forcelsand promote cel attachment and retainceldifferentiation ability.Degradable polymer composite materials have good biocompatibility, whose mechanical properties, degradation rate and microstructure can be controled, and they can be mass-produced according to the design requirements.Thecomposite materials inheriting the advantages of natural biomaterials and synthetic polymer materials have become the most ideal scaffold materials and wil be a research focus in the future.关键词
生物材料/材料相容性/组织工程/血管/支架材料/血管移植分类
医药卫生引用本文复制引用
潘兴纳,李亚雄,蒋立虹..组织工程血管支架材料的研究与进展[J].中国组织工程研究,2016,20(34):5149-5154,6.基金项目
云南省科技厅-昆明医科大学联合专项基金资助项目(2013FB187，2013FB189)；云南省卫生科技计划项目(2014NS208，2014NS209)@@@@the Joint Special Fund Project of Yunnan Provincial Science and Technology Department-Kunming Medical University, No.2013FB187,2013FB189 （2013FB187，2013FB189）
the Health Science and Technology Project of Yunnan, No.2014NS208,2014NS209 （）
