中国感染控制杂志2016，Vol.15Issue(8)：556-560,5.DOI:10.3969/j.issn.1671-9638.2016.08.005
强化胰岛素治疗对急性脑卒中医院感染率影响的Meta分析
Effect of intensive insulin treatment on healthcare-associated infection rate in acute stroke:A Meta-analysis
摘要
Abstract
Objective To evaluate effect of intensive insulin treatment(IIT)on healthcare-associated infection (HAI)rate in patients with acute stroke and stress hyperglycemia.Methods Databases,including PubMed,Em-base,Cochrane Library,WanFang,and China National Knowledge Infrastructure(CNKI)Data,were electronically searched,relevant journals and references of the included literatures were also searched manually,literatures were selected according to the uniform inclusion and exclusion criteria,incidence of HAI and mean blood glucose in patients who received IIT for acute stroke were assessed systematically.Results A total of 13 randomized controlled trials (RCT)involving 1 032 patients were included in this systematic review.Meta-analysis results showed that 10 studies involving 832 patients were finally enrolled for comparing HAI rate, HAI rates in IIT group and conventional insulin treatment group were 28.3% and 56.1 %,respectively(Z =4.50 ),difference between two groups was statistically significant (RR=0.53 [95 %CI :0.40 to 0.70],P <0.001 );A total of 328 patients in 5 studies were finally included in the comparison of blood glucose,difference in mean blood glucose between two groups was statistically significant(MD =-2.52 [95% CI :-4.30 to -0.74],P =0.006).Funnel plot of HAI rate revealed that there was publication bias.Conclusion IIT is used for the regulation of stress hyperglycemia in acute stroke,it can reduce the incidence of HAI and blood glucose in patients.关键词
急性脑卒中/应激性高血糖/强化胰岛素治疗/院内感染/血糖/医院感染/Meta分析Key words
acute stroke/stress hyperglycemia/intensive insulin treatment/healthcare-associated infection/blood glucose/Meta-analysis分类
医药卫生引用本文复制引用
杨中良,杨秀云,黄飞华,郭梅凤,孙宝玲,赵明珠..强化胰岛素治疗对急性脑卒中医院感染率影响的Meta分析[J].中国感染控制杂志,2016,15(8):556-560,5.基金项目
上海市卫生和计划生育委员会科研基金（201440472）；浦东新区科技发展创新基金 （）
