中国感染控制杂志2016，Vol.15Issue(8)：561-569,9.DOI:10.3969/j.issn.1671-9638.2016.08.006
我国肺癌患者医院感染高危因素Meta分析
Risk factors for healthcare-associated infection in patients with lung cancer in China:A Meta-analysis
摘要
Abstract
Objective To analyze risk factors and complication characteristics of healthcare-associated infection (HAI)in patients with lung cancer,and provide evidence for the formulation of HAI management strategy. Methods HAI-related articles were retrieved from China Biology Medicine (CBM),China National Knowledge Infrastructure (CNKI),Wanfang database,Vip database,PubMed,and Embase,all data were conducted Meta-analysis.Results A total of 19 articles involving 8 069 hospitalized patients with lung cancer (1 280 had HAI)were included.Meta-analysis on combined values of medical factors for HAI were as follows:OR(95%CI )of anti-tumor therapy(radiotherapy and chemotherapy),number of chemotherapy (≥ 2 times ),antimicrobial prophylaxis, immunosuppressant therapy,and invasive operation were 3.13 (1 .82,5.39),9.20 (3.04,27.87),3.23 (1 .77, 5.91),2.00(1 .56,2.57),and 2.28(1 .81 ,2.88),respectively;Meta-analysis on combined values of complication factors for HAI were as follows:OR (95% CI )of pulmonary diseases,chronic obstructive pulmonary disease (COPD),diabetes,renal dysfunction,malnutrition,hypoalbuminemia,neutropenia,and leukopenia were 2.65 (1 .74,4.02),2.40 (1 .76,3.27),2.25 (1 .85,2.73 ),2.56 (1 .18,5.52),5.51 (1 .70,17.89),2.05 (1 .56, 2.70),3.38(1 .40,8.18),and 2.10 (1 .22,3.62),respectively.Conclusion HAI-related factors of medical treat-ment and complications in patients with lung cancer are diversity,risk factors for HAI in patients with lung cancer are anti-tumor therapy,immunosuppressant therapy,antimicrobial prophylaxis,invasive operation,pulmonary dis-eases,COPD,diabetes,renal dysfunction,malnutrition,hypoalbuminemia,neutropenia,and leucopenia.关键词
肺癌/医院感染/医疗因素/合并症/Meta 分析Key words
lung cancer/healthcare-associated infection/medical factor/complication/Meta-analysis分类
医药卫生引用本文复制引用
肖政,刘莲花,汪成琼,楚亚林,胡世芸,邱隆敏,余昌胤..我国肺癌患者医院感染高危因素Meta分析[J].中国感染控制杂志,2016,15(8):561-569,9.基金项目
贵州省哲学社会科学规划基金（14GZYB58）；遵义医学院博士启动基金 （）
