中国感染控制杂志2016，Vol.15Issue(8)：576-578,582,4.DOI:10.3969/j.issn.1671-9638.2016.08.009
儿童下呼吸道肺炎链球菌感染临床特征及耐药性
Clinical features and antimicrobial resistance of lower respiratory tract in-fection with Streptococcus pneumoniae isolated from children
摘要
Abstract
Objective To explore clinical features and antimicrobial resistance of lower respiratory tract infection (LRTI)with Streptococcus pneumoniae (S .pneumoniae)isolated from children in Nanjing.Methods Clinical data of children with confirmed S .pneumoniae LRTI through sputum culture at a children’s hospital in Nanjing between July 2013 and June 2014 were analyzed retrospectively,S .pneumoniae strains were performed antimicrobial susceptibility testing through K-B method and minimum inhibitory concentration (MIC)testing.Results Among 197 children with S .pneumoniae infection,72.59% were <3 years old,63.96% occurred in autumn and winter, 57.87% had elevated leukocyte count,cough and fever were the most common clinical symptoms,complications of digestive and circulatory system were also common.The resistance rates of S .pneumoniae to azithromycin, penicillin,and erythromycin were 94.92%, 92.98%, and 88.83% respectively; the sensitivity rates to vancomycin,chloramphenicol,meropenem,ceftriaxone,and ofloxacin were all > 90%,vancomycin was up to 98.98%.Conclusion The percentage of S .pneumoniae LRTI is high in children < 3 years old,most occur in autumn and winter,resistance rates to azithromycin,penicillin,and erythromycin are all high,antimicrobial agents should be selected for the treatment of infection according to antimicrobial susceptibility testing.关键词
儿童/肺炎链球菌/下呼吸道/耐药性/抗药性,微生物/药敏试验/合理用药Key words
child/Streptococcus pneumoniae/lower respiratory tract infection/drug resistance,microbial/anti-microbial susceptibility testing/rational drug use分类
医药卫生引用本文复制引用
李立群,胡静,周凯,谢国锦,王晓卫..儿童下呼吸道肺炎链球菌感染临床特征及耐药性[J].中国感染控制杂志,2016,15(8):576-578,582,4.基金项目
南京市医学科技发展项目 （）
