中国康复理论与实践2016，Vol.22Issue(8)：876-883,8.DOI:10.3969/j.issn.1006-9771.2016.08.002
督脉电针对不同时间段脊髓损伤大鼠运动功能及p75神经营养素受体表达的影响
Effects of Governor Vessel Electroacupuncture in Different Time Points on Motor Functions and p75 Neurotroph-in Receptor after Spinal Cord Injury
摘要
Abstract
Objective To explore the effect of Governor Vessel electroacupuncture in different time points on motor function and p75 neurotrophin receptor (p75NTR) after spinal cord injury. Methods A total of 180 adult male Sprague-Dawley rats were randomly divided into three groups (one day, three days and seven days after modeling), and each group was divided into normal control group, normal electroacu-puncture group, sham operation group, model group and Governor Vessel electroacupuncture group with 12 cases in each group. The spinal cord injury model was established with the modified Allen's method. The normal electroacupuncture group and the Governor Vessel elec-troacupuncture group received electroacupuncture on Dazhui (DU14) and Mingmeng (DU04) acupoints. Basso-Beattic-Bresnahan (BBB) Scale was performed to assess the motor function of rats. The expression of p75NTR was detected with Western blotting. Results The BBB score of the model group and the Governor Vessel electroacupuncture group were significantly lower than that of the other three groups. The BBB score was significantly higher in the Governor Vessel electroacupuncture group than in the model group seven days after intervention (t=-4.510, P<0.001). The expression of p75NTR was siginificantly lower in the Governor Vessel electroacupuncture group than in the model group (P<0.01). Conclusion The expression of p75NTR increased after spinal cord injury. Governor Vessel electroacupuncture could improve the motor function, and inhibit the p75NTR expression of damaged spinal cord tissues.关键词
脊髓损伤/督脉/电针/p75神经营养素受体/凋亡/大鼠Key words
spinal cord injury/Governor Vessel/electroacupuncture/p75 neurotrophin receptor/apoptosis/rats分类
医药卫生引用本文复制引用
吕威,时素华,莫雨平,李冰,姚海江,景泉凯,宋良玉,王鑫,毛颖秋,李志刚..督脉电针对不同时间段脊髓损伤大鼠运动功能及p75神经营养素受体表达的影响[J].中国康复理论与实践,2016,22(8):876-883,8.基金项目
国家自然科学基金项目(No.81373728)。 （No.81373728）
