中国康复理论与实践2016，Vol.22Issue(8)：911-913,3.DOI:10.3969/j.issn.1006-9771.2016.08.007
瞬时受体电位A1通道在神经病理性疼痛中的研究进展
Transient Receptor Potential Ankyrin 1 Channel in Neuropathic Pain (review)
摘要
Abstract
Transient receptor potential ankyrin 1 (TRPA1) is a family member of the transient receptor potential (TRPs). It is primarily localized to a subpopulation of primary sensory neurons, such as trigeminus, vagus and dorsal root ganglia. Neuropathic pain is often caused by peripheral nerve injury, diabetes and chemotherapeutics. A large of oxidative/nitrative stress products are produced during neuropathic pain, which cause acute nociception, allodynia, and hyperalgesia. TRPA1 antagonists may be beneficial in the treatment of neuropathic pain. Here, the role of TRPA1 in neuropathic pain is summarized.关键词
瞬时受体电位A1/神经病理性疼痛/氧化性应激/硝化应激/综述Key words
transient receptor potential ankyrin 1/neuropathic pain/oxidative stress/nitrative stress/review分类
医药卫生引用本文复制引用
张林净,刘若卓,于生元..瞬时受体电位A1通道在神经病理性疼痛中的研究进展[J].中国康复理论与实践,2016,22(8):911-913,3.基金项目
北京市自然科学基金面上项目(No.7162178)。 （No.7162178）
