中国免疫学杂志2016，Vol.32Issue(8)：1112-1117,6.DOI:10.3969/j.issn.1000-484X.2016.08.006
青霉素诱导的大鼠癫痫模型中STAT3及IL－6表达
Expression of STAT3 and IL-6 in epilepsy rat caused by penicillin
摘要
Abstract
Objective:To investigate the expression of IL-6 and STAT3 in the epilepsy rat caused by penicillin .Methods:The model of epilepsy in rats was made by abdominal injecting penicillin .Then the EEG and behavior was observed in each group and the level of IL-6/STAT3 transcription and cytokine IL-6 secretion in different groups was compared using qRT-PCR and ELISA respectively.The protein expression of STAT3 was detected using Western blot.Results: 500 U/kg and 800 U/kg rats injected penicillin were induced epilepsy and show typical epileptic seizures behavioral and brain waves ,seizures was 100%;the level of IL-6/STAT3 transcription and IL-6 secretion in the model of epilepsy was significantly higher than control .There was no significant difference in the expression of STAT3 protein levels,but a significant increase in p-STAT3.Conclusion:Expression of STAT3 and IL-6 plays an important role in the Epilepsy Rat caused by penicillin .关键词
癫痫/大鼠/STAT3/IL-6Key words
Epilepsy/Rat/STAT3/IL-6分类
医药卫生引用本文复制引用
陈恩,林琳,吕赛平,陈杰妮,陈纯静,邹学森..青霉素诱导的大鼠癫痫模型中STAT3及IL－6表达[J].中国免疫学杂志,2016,32(8):1112-1117,6.基金项目
本文受江西省卫生厅中医药科研基金项目（2013B006）资助。 （）
